Scientist, Genome Engineering
An affiliate of Colossal is hiring a Scientist to develop and implement genome engineering strategies for non-model mammalian organisms. The candidate will design and produce reagents for CRISPR/Cas9, prime editing, base editing, and additional modalities as needed; develop strategies for multiplex genome editing coupled with comprehensive genotyping assays; and independently analyze editing outcomes using appropriate bioinformatics tools. This hands-on role requires a scientist with established technical expertise who can contribute immediately, innovate, and collaborate closely with Cell Engineering teams responsible for cellular delivery and production of edited cell lines.
This position is based on-site in Dallas, TX. Relocation assistance is available.
Duties and Responsibilities:
- Design, execute, and optimize CRISPR/Cas9, prime editing, and base editing strategies, including multiplex editing of multiple genomic targets.
- Design and generate guide RNAs, pegRNAs, donor templates, expression constructs, and other genome editing reagents; oversee their validation and quality control.
- Innovate and troubleshoot editing strategies to improve efficiency, specificity, reproducibility, and scalability in non-model mammalian systems.
- Apply knowledge of molecular genetics and DNA repair pathways to guide editing
