Founder in Residence, Unlocking systemic drug delivery for brain & CNS disease

Join us to build: we’re seeking entrepreneurially-minded scientists with deep technical expertise, who are eager to solve one of the most durable and consequential challenges in medicine through venture building. This role offers a unique opportunity to work at the forefront of CNS drug delivery, leading a company that makes it fundamentally easier, safer and more broadly applicable to get therapeutics into the brain.

The role is full-time, remote initially until venture incorporation and spin-out (circa end of 2027), location TBD.

The Opportunity

CNS diseases represent one of the largest and most persistent unmet needs in medicine. Over 1 billion people worldwide live with a neurological condition, yet disease-modifying treatments remain elusive for the vast majority - from Alzheimer’s and Parkinson’s to multiple sclerosis and rare paediatric neurological disorders. The failure rate in CNS drug development is among the highest of any therapeutic area, and a central reason is not a lack of therapeutic targets: it is our inability to reliably deliver drugs across the blood-brain barrier (BBB).

The BBB is a highly specialised endothelial barrier that protects the brain from pathogens and toxins - but in doing so, it excludes the vast majority of therapeutic molecules. Fewer than 2% of small molecules cross the BBB in meaningful quantities, and almost no large-format biologics - antibodies, proteins, nucleic acids - reach the