Principal / Senior Principal Scientist, DMPK

Reporting to the Chief Scientific Officer, this role leads DMPK strategy and oversees bioanalytical work across nonclinical and clinical programs, operating as a hands-on scientific leader. We are looking for an accomplished DMPK scientist with experience in PK and PK-PD study design, PK data analysis and interpretation, and translational biomarker strategy. This person will support pharmacology and nonclinical toxicology programs, providing broader context across the nonclinical development portfolio. The ideal candidate brings deep scientific expertise and a hands-on approach and thrives in the fast-paced environment of a clinical-stage biotech where both scientific and strategic contributions are expected.

Responsibilities

• Lead DMPK strategy and oversee bioanalytical work across nonclinical and clinical programs, including PK, biomarker, and translational PD readouts
• Oversee development, qualification, and validation of nonclinical and clinical bioanalytical assays (GLP/GCP-compliant as required), as well as sample analysis, working with internal and CRO analytical scientists
• Design, execute, and oversee PK and PK-PD studies of tRNAs to evaluate delivery technologies (LNP and others), biodistribution, and biomarker effects
• Lead PK and PK-PD data analysis and interpretation across mouse, rat, NHP, and human studies to support