Research Associate

HAYA Therapeutics is a precision therapeutics company based at the life sciences park Biopôle SA in Lausanne, Switzerland, and JLABS, San Diego, USA. Haya Therapeutics is developing novel tissue-specific antisense oligonucleotide drugs targeting long noncoding RNAs in fibrotic diseases including heart, lungs, kidney, liver, and cancers.

1.     Purpose of the role:

Develop and execute cutting-edge cell and molecular biology assays in immunology models to identify novel long non-coding RNA (lncRNA) targets and advance pioneering therapeutic applications.

Requirements

1.     Accountabilities

• Maintain and differentiate primary immune cells and cell lines (including T-cells, NK cells, Macrophages, and B cells) to establish robust in vitro immunology models.
• Execute multi-color flow cytometry (FACS) runs to monitor immune cell identity markers and perform phenotypic characterization.
• Conduct immunoassays (ELISA/MSD) for cytokine profiling to evaluate cellular immune responses and target engagement.
• Execute ASO/siRNA compound screenings in primary immune cells to measure on-target gene knockdown efficiency via qPCR and Next-Generation Sequencing (NGS).
• Perform high-quality library preparation for NGS platforms (including bulk RNA-seq, single-cell/nucleus snRNA-seq/snATAC-seq, and ChIP-seq/HiC) to map genome-wide c