Senior/Principal Scientist, Small Molecule Therapeutics

Your Impact at LILA

The Senior/Principal Scientist, Small Molecule Therapeutics will lead early hit identification efforts, leveraging their expertise in DNA-encoded libraries (DEL) and complementary screening technologies to discover and validate novel chemical matter.  This role will partner cross-functionally with Lila’s Chemistry, Computational, and Automation teams to develop and scale a best-in-class small molecule screening platform.  The Senior/Principal Scientist will also drive the progression of hits through optimized biochemical and biophysical assay cascades, while identifying and securing fit-for-purpose protein sources to enable robust characterization and follow-up.  

What You'll Be Building

• Build and continuously improve DNA-encoded library (DEL) screening capabilities, tightly integrated with Lila’s AI-enabled chemistry design engine and automated/robotic synthesis platform.
• Design and execute DEL screening campaigns, including selection strategy, experimental execution, data interpretation, and translation into robust hit validation and hit-to-lead workflows.
• Develop, optimize, and run fit-for-purpose biochemical and biophysical assays to validate and characterize hits emerging from Lila’s scree