Senior Bioinformatics Scientist

Natera is seeking a Senior Bioinformatics Scientist to join our Bioinformatics Research team and help build the machine learning models behind Natera's tissue-free, methylation-based assay. These will be the models that detect cancer in the minimal residual disease (MRD) setting and help inform treatment selection. The ideal candidate brings a strong background in algorithm development, genomics, sequencing data processing, and applied machine learning.

Primary Responsibilities:

• Develop, train, and evaluate machine learning models, driving algorithm design decisions that support cancer detection in the MRD setting.
• Own end-to-end research analyses, from ideation through implementation (scripts and notebooks), troubleshooting, and performance evaluation, including developing new features within existing pipelines.
• Translate between wet-lab experimental design and computational analysis, navigating ambiguity as assay requirements evolve and maintaining rigorous quality control across high-volume sequencing data spanning multiple cohorts, vendors, and clinical protocols.
• Communicate findings and model performance to both technical and cross-functional stakeholders, and cont