Director of Toxicology

Location:  This position may be performed remotely, but requires the flexibility and willingness to travel as needed.

The Opportunity

As Director, Toxicology, you will provide scientific, strategic, and regulatory leadership for nonclinical safety activities across Praxis’s growing portfolio of novel small molecule and antisense oligonucleotide (ASO) therapies for CNS disorders. 

You will own toxicology strategy for designated programs and lead nonclinical safety activities from discovery and candidate selection through IND-enabling development and toward NDA/MAA. You’ll provide hands-on scientific leadership, interpret emerging safety findings, and translate complex data into clear recommendations for program teams, leadership, and regulatory authorities. 

You’ll thrive in this role if you bring deep toxicology expertise, strong regulatory judgment, and an ownership mindset. You anticipate risks, challenge assumptions, navigate ambiguity, and develop pragmatic paths forward—helping Praxis advance promising medicines to patients with speed and scientific rigor. As the function grows, the Director may assume responsibility for leading and developing direct reports by establishing clear priorities, providing scientific guidance and constructive feedback, and