Cellular Biologist

Topos Bio

At Topos Bio, we're pioneering drug discovery for intrinsically disordered proteins—targets that have eluded conventional approaches in neurodegeneration, oncology, and cardiometabolic disease.

We're seeking a cell biologist to develop and execute cell-based assays for validating computational predictions and supporting medicinal chemistry efforts. You'll work at the interface of disease biology, protein biophysics, and drug screening.

What you will do

• Develop and optimize mammalian cell-based assays for disordered protein targets

• Execute phenotypic and reporter-based screening campaigns to validate computational hits

• Characterize compound activity and support structure-activity relationship studies

• Collaborate with computational scientists to integrate experimental data with modeling workflows

• Establish robust assay protocols and quality control metrics

What we are looking for

• Strong foundation in mammalian cell culture and cellular assay development

• Experience with dise