Scientist
• We are seeking a highly motivated, results-oriented, self-starter who demonstrates personal accountability for outcomes and thrives on increasing levels of responsibility, to join a new and dynamic team responsible for successful development and characterization of clinical-scale manufacturing processes for Chimeric Antigen Receptor T cell (CART) therapies.
• The successful candidate will contribute to the development and implementation of processes for lab-scale production and characterization of high-quality lentiviral vector (LVV) and its application for engineering CART cells.
Job Responsibilities:
• Actively contribute to development and characterization, and successful execution of robust LVV production processes adherent and/ or suspension-based production, purification and formulation.
• Contribute to optimization of LVV transduction for CART manufacturing processes development as appropriate
• Contribute to innovation programs to enhance LVV and CART manufacturing technologies/ capabilities and work-processes as appropriate
• Contribute to Project Technical Teams and communicate and collaborate effectively to ensure effective interactions with all stakeholder groups
• Ensure high-quality, timely documentation in electronic laboratory notebooks and Technical Reports and contribute to Regulatory Filings and responses to Regulatory questions as appropriate.
• Present data/ strategy to scientists (and management) in internal venues (technical meetings, Project Team meetings) as appropriate.
Education & Experience:
BSc/ MSc with 5+ years or PhD degree in Virology/ Molecular Immunology/ Molecular Biology or related field or Chemical Engineering degree (with appropriate viral vector experience); experience with viral vector production/ purification processes and disposable manufacturing technologies a plus.
Technical Skills Requirements:
- Development and/ or execution of LVV/ other viral vector production and purification processes
- Molecular virology/ engineering and/ or production of recombinant viruses
- Culture of primary T cells, T cell molecular biology/ engineering
Additional Skills:BS/MS degree with 5+ years experience required, or PhD
Best Regards,
Anuj Mehta
973-967-3402